Los Santos Zone (Spanish: Zona de los Santos) is a mountainous region in the San José Province of Costa Rica, in the center-south of the country. It is also known in Spanish as Valle de los Santos or just Los Santos.
It corresponds to a wide sector of a series of intermontane valleys composed by the cantons of Tarrazú, Dota and León Cortés Castro. The nearby districts of San Cristóbal and Frailes, both of Desamparados canton, are under the socioeconomic influence of the zone.
The region is recognized as a major coffee production zone in the country. Apples are also cultivated in the region.