The municipality of Chichiquila is located in the far east of the state of Puebla in the Sierra Madre Oriental and on the skirts of the Citlaltépetl or Pico de Orizaba volcano. It has a total territorial extension of 109,721 square kilometers. Its altitude ranges from a maximum of 2400 and a minimum of 1200 meters above sea level.
The municipality borders the municipality to the north and west with the municipality of Quimixtlán. To the northeast, east and south it borders the state of Veracruz de Ignacio de la Llave . to the northeast with the municipality of Ixhuacán de los Reyes, to the east with the municipality of Tlaltetela and with the municipality of Huatusco, to the southeast with the municipality of Coscomatepec and to the south with the municipality of Calcahualco.
Chichiquila means "place where bitter grass abounds.